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1.发明公开STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AGAINST ELECTRON TRANSPORT-DEFICIENT MICROBES AND AS POTENTIATORS FOR ANTIMICROBIAL AGENTS AGAINST PATHOGENIC BACTERIA 审中-公开STEROIDALKALOIDDERIVATE及其作为抗菌药物对具有电子传输芽和缺乏作为增效剂用于抗微生物活性物质致病细菌上
公开(公告)号：EP2675822A1
公开(公告)日：2013-12-25
申请号：EP12747258.7
申请日：2012-02-15
发明人： MALOUIN, François , MITCHELL, Gabriel , BOUARAB, Kamal , MARSAULT, Eric , CHAGNON, Félix , BOULANGER, Simon , GUAY, Isabelle
CPC分类号： A61K31/58 , A01N45/00 , A61K31/395 , A61K31/7036 , A61L2/16 , C07J7/002 , C07J7/006 , C07J7/007 , C07J7/0085 , C07J41/005 , C07J41/0055 , C07J43/003 , C07J43/006 , C07J51/00 , G01N2800/52 , A61K2300/00
摘要： The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular or intracellular electron transport-deficient microbes and/or increase the antimicrobial activity of aminoglycoside antibiotics against their targets, and which are useful as antibacterial agents for treatment or prophylaxis of monomicrobiotic or polymicrobic bacterial infections or for the reduction of antibiotic resistance development in animals or in humans, or for use as antiseptics or agents for sterilization or disinfection.
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