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1.发明公开
公开(公告)号：EP2035007A1
公开(公告)日：2009-03-18
申请号：EP07765472.1
申请日：2007-06-18
发明人： ZIEGLER, Dieter , WITTE, Klaus , HOCHER, Berthold , FISCHER, Yvan
IPC分类号： A61K31/519 , A61K51/00 , A61P13/12
CPC分类号： A61K31/519
摘要： The present invention relates to pharmaceutical combinations comprising a therapeutically effective amount of at least one selective adenosine A1 antagonist and at least one radiocontrast media. In particular, the present invention relates to pharmaceutical combinations comprising 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-trans-cyclohexanol methanesulfonate and/or (4S)-4-hydroxy-1-(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-L- prolinamide methanesulfonate as selective adenosine A1 antagonists and at least one radiocontrast media. The invention also relates to the use of said combinations in the manufacture of a medicament for the treatment of radiocontrast media induced nephropathy. Furthermore, the invention is relating to a kit comprising a therapeutically effective amount of said combination of at least one selective adenosine A1 antagonist and at least one radiocontrast media.
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2.发明公开
公开(公告)号：EP1687006A1
公开(公告)日：2006-08-09
申请号：EP04818828.8
申请日：2004-11-15
CPC分类号： A61K31/55
摘要： The present invention relates to a novel use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the α-position to the nitrogen atom and are substituted in position 3 by a 1- (carboxyalkyl)cyclopentylcarbonylamino radical, and/or of their salts and biolabile esters, and/or of physiologically acceptable solvates thereof, in larger mammals and particularly in humans, preferably human patients having diabetes, and to the production of pharmaceutical compositions and products suitable for the novel treatment. The invention particularly relates to the treatment and/or prophylaxis of renal dysfunction, disease or disorder, preferably in diabetic patients, but in a broader sense also in patients with syndrome X or in particular in patients with a renal dysfunction, disease and /or disorder, which patients are in addition hypertensive, obese, hyperglycemic and/or subject to metabolic disorder.
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公开(公告)号：EP1687006B1
公开(公告)日：2007-11-14
申请号：EP04818828.8
申请日：2004-11-15
CPC分类号： A61K31/55
摘要： The present invention relates to a novel use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the α-position to the nitrogen atom and are substituted in position 3 by a 1- (carboxyalkyl)cyclopentylcarbonylamino radical, and/or of their salts and biolabile esters, and/or of physiologically acceptable solvates thereof, in larger mammals and particularly in humans, preferably human patients having diabetes, and to the production of pharmaceutical compositions and products suitable for the novel treatment. The invention particularly relates to the treatment and/or prophylaxis of renal dysfunction, disease or disorder, preferably in diabetic patients, but in a broader sense also in patients with syndrome X or in particular in patients with a renal dysfunction, disease and /or disorder, which patients are in addition hypertensive, obese, hyperglycemic and/or subject to metabolic disorder.
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