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    3,5-Dioxa-8-aza-tricyclo(5.2.1.00,0)decane-9-methanols, their metal complexes and enantioselective hydrogenation processes
    2.
    发明公开
    3,5-Dioxa-8-aza-tricyclo(5.2.1.00,0)decane-9-methanols, their metal complexes and enantioselective hydrogenation processes 有权
    3,5-二氧代-8-氮杂 - 三环（5.2.1.00,0）癸烷-9-甲醇，其中Metallkomplexe und ihre Verwendung zur对映体

    公开(公告)号：EP1146047A1

    公开(公告)日：2001-10-17

    申请号：EP01109043.8

    申请日：2001-04-11

    申请人： Solvias AG

    发明人： Andersson, Pher G. ,  Nordin Sofia J.M. ,  Roth, Peter

    IPC分类号： C07D491/08 ,  C07B53/00

    CPC分类号： C07D491/08 ,  C07B53/00

    摘要： Compounds of the formula I, in the form of their racemates, mixtures of stereoisomers or mainly pure stereoisomers
    in which

    Y is C 1 -C 4 alkylene or -SiR 1 R 2 -;
    X is a carbon atom and A 1 and A 2 independently of one another are hydrogen, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, C 3 -C 8 cycloalkyl-C 1 -C 4 alkyl, C 3 -C 8 cycloalkenyl-C 1 -C 4 alkyl, C 6 -C 10 aryl or C 7 -C 14 aralkyl; or
    X is a silicon atom and A 1 and A 2 independently of one another are C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 4 alkyl, C 6 -C 10 aryl or C 7 -C 14 aralkyl;
    A 3 and A 4 independently of one another are hydrogen, C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 alkyl, C 6 -C 10 aryl or C 7 -C 14 aralkyl; and
    R 1 and R 2 independently of one another are C 1 -C 6 alkyl, cyclohexyl, phenyl or benzyl,
    are ligands for metal complexes of the eighth sub-group of the Periodic Table of the Elements, which are suitable as catalysts for asymmetric hydrogenations and transfer hydrogenations of prochiral compounds having carbon/carbon or carbon/heteroatom multiple bonds.

    摘要翻译： 式I的化合物，其外消旋物形式，立体异构体的混合物或主要是纯的立体异构体，其中Y是C 1 -C 4亚烷基或-SiR 1 R 2 - ; X是碳原子，且A 1和A 2彼此独立地是氢，C 1 -C 12烷基，C 2 -C 12烯基，C 3 -C 8环烷基，C 3 -C 8环烯基，C 3 -C 8环烷基-C 1 -C 4烷基，C 3 -C 8环烯基-C 1 -C 4烷基， C 10芳基或C 7 -C 14芳烷基; 或X为硅原子，且A 1和A 2彼此独立地为C 1 -C 12烷基，C 3 -C 8环烷基，C 3 -C 8环烷基-C 1 -C 4烷基，C 6 -C 10芳基或C 7 -C 14芳烷基; A3和A4彼此独立地是氢，C 1 -C 12烷基，C 3 -C 8环烷基，C 3 -C 8 - 环烷基-C 1 -C 4烷基，C 6 -C 10芳基或C 7 -C 14芳烷基; R 1和R 2彼此独立地是C 1 -C 6烷基，环己基，苯基或苄基，是元素周期表第八子基团的金属络合物的配体，它们适合作为不对称氢化和转移氢化的催化剂 具有碳/碳或碳/杂原子多键的前手性化合物。