公开(公告)号：EP3164149A1

公开(公告)日：2017-05-10

申请号：EP15787666.5

申请日：2015-07-01

申请人： Spherium Biomed S.L. ,  Universidad De Zaragoza

发明人： ORTIZ SAGRISTA, Jordi ,  BOSSER ARTAL, Ramon ,  MORENO MARTINEZ, Laura ,  CALVO ROYO, Ana Cristina ,  MUNOZ GONZALVO, Maria Jesus ,  ZARAGOZA FRNANDEZ, Pilar ,  OSTA PINZOLAS, Rosario

IPC分类号： A61K38/16 ,  A61K38/48 ,  A61P21/00

CPC分类号： A61K38/4886 ,  A61K48/005 ,  C12Y304/24068

摘要： The present disclosure relates to the use of the non-toxic proteolytic C fragment of tetanus toxin and plasmids encoding such protein fragment to increase muscle mass and/or muscle strength in a subject in need thereof. As such, methods of ameliorating the severity of a pathological condition characterized, at least in part, by a decreased amount, development, or metabolic activity of muscle are provided. The disclosed compositions and method are also useful for the treatment of condition in which increase in muscle mass and muscle strength are desirable, including cosmetic uses.

摘要翻译： 本公开涉及破伤风毒素的无毒蛋白水解C片段和编码该蛋白片段的质粒在需要其的受试者中增加肌肉质量和/或肌肉强度的用途。 如此，提供了改善至少部分地由肌肉的减少的量，发育或代谢活性为特征的病理状态的严重性的方法。 所公开的组合物和方法也可用于治疗需要增加肌肉质量和肌肉强度的病症，包括美容用途。