公开(公告)号：EP3349743A1

公开(公告)日：2018-07-25

申请号：EP16847549.9

申请日：2016-09-19

申请人： St. Jude Children's Research Hospital ,  Memorial Sloan-Kettering Cancer Center

发明人： MIN, Jaeki ,  SCOTT, Daniel, C. ,  BHASIN, Deepak ,  SCHULMAN, Brenda, A. ,  SINGH, Bhuvanesh ,  HAMMILL, Jared, T. ,  GUY, R., Kiplin

IPC分类号： A61K31/17 ,  A61K31/445 ,  C07D211/58 ,  C07D401/12

CPC分类号： A61K31/4545 ,  A61K31/17 ,  A61K31/437 ,  A61K31/451 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/506 ,  A61P15/16 ,  A61P31/04 ,  A61P31/12 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/06 ,  C07D471/04

摘要： In one aspect, the invention relates to substituted 1-phenyl-3-(piperidin-4-yl)urea analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the DCN1-UBC12 interaction inhibitors of DCN1-mediated cullin-RING ligase activity, methods of making same, pharmaceutical compositions comprising same, methods of treating disorders using the disclosed compounds and compositions, methods of treating disorders associated with a DCN1-UBC12 interaction dysfunction, methods of treating disorders associated with a DCN1-mediated cullin-RING ligase activity dysfunction, methods of male contraception comprising the disclosed compounds and compositions, and kits comprising the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.