公开(公告)号：EP3492477A1

公开(公告)日：2019-06-05

申请号：EP17834146.7

申请日：2017-07-20

申请人： Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

发明人： HATTORI, Yoshihide ,  UEHARA, Kohki ,  KIRIHATA, Mitsunori

IPC分类号： C07F5/05 ,  A61K31/69 ,  A61K41/00 ,  A61P35/00

摘要： To provide a novel boron-containing compound. A compound represented by the following formula: wherein black circle represents B, white circles represent B-H; -R 1 represents -(CH 2 )n-X 1 -R 3 (n represents an integer of 0 to 6; X 1 represents O, S, NH, S-S, O-CO, NHCO or SCO, or does not exist; R 3 represents C 6 -C 20 alkyl, hydroxy C 6 -C 20 alkyl, amino C 6 -C 20 alkyl, azido C 6 -C 20 alkyl, hydroxycarbonyl C 6 -C 20 alkyl, or the like), or a group having a repeating sequence of -(CH 2 ) 2 -O- 3 times or more and 10 times or less and having a methyl group or an ethyl group at the end on the oxygen atom side; and -R 2 is - (CH 2 )m-X 2 -R 4 (m represents an integer from 0 to 8; X 2 represents O, S, NH, S-S, O-CO, NHCO or SCO, or does not exist; and R 4 represents a tumor recognition moiety), or does not exist are prepared and used.