公开(公告)号：EP2320951B1

公开(公告)日：2016-01-06

申请号：EP09787810.2

申请日：2009-07-29

申请人： Stewart Italia SRL ,  Rimoli, Maria Grazia ,  Calignano, Antonio ,  Cuomo, Rosario ,  Boatto, Gianpiero

发明人： ABIGNENTE, Enrico ,  MELISI, Daniela ,  CURCIO, Annalisa ,  LUONGO, Elvira ,  LA RANA, Giovanna ,  SASSO, Oscar ,  SARNELLI, Giovanni ,  RUSSO, Roberto ,  NIEDDU, Maria ,  CIRILLO, Carla ,  DE LUCIA, Salvatore

IPC分类号： A61K47/48 ,  A61P29/00 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10 ,  A61K31/7024

CPC分类号： A61K31/7024 ,  A61K47/549 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

公开(公告)号：EP2320951A2

公开(公告)日：2011-05-18

申请号：EP09787810.2

申请日：2009-07-29

申请人： Stewart Italia SRL ,  Rimoli, Maria Grazia ,  Calignano, Antonio ,  Cuomo, Rosario ,  Boatto, Gianpiero

发明人： ABIGNENTE, Enrico ,  MELISI, Daniela ,  CURCIO, Annalisa ,  LUONGO, Elvira ,  LA RANA, Giovanna ,  SASSO, Oscar ,  SARNELLI, Giovanni ,  RUSSO, Roberto ,  NIEDDU, Maria ,  CIRILLO, Carla ,  DE LUCIA, Salvatore

IPC分类号： A61K47/48 ,  A61P29/00

CPC分类号： A61K31/7024 ,  A61K47/549 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

摘要： Pro-drugs of all non-steroidal anti-inf lammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L- enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine,
N -acetyl glucosamine,
N -acetyl galactosamine,
N -acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.