公开(公告)号：EP1853228A2

公开(公告)日：2007-11-14

申请号：EP06780513.5

申请日：2006-03-01

申请人： Sun Pharmaceutical Industries Limited

发明人： KHOPADE, Ajay, SUN PHARMA ADVANCED RESEARCH CENTRE ,  GEORGE, Alex, SUN PHARMA ADVANCED RESEARCH CENTRE ,  BHOWMICK, Subhas Balaram, SUN PHARMA ADV. RES. CTR

IPC分类号： A61K9/16

CPC分类号： A61K9/1647 ,  A61K9/5031

摘要： A process for the manufacture of free-flowing uniformly sized microspheres for the sustained release of therapeutically active ingredient comprising: a) preparing a first dispersed phase comprising a therapeutically active ingredient, a biodegradable polymer and an organic solvent; b) mixing the first dispersed phase with a aqueous phase to form an emulsion; c) spraying the emulsion into a vessel (20) equipped with organic solvent removal means; d) passing the suspension of microspheres through screens and collecting a fractionated size of the microspheres on the surface of the screens; e) drying the microspheres wherein steps a to e are carried out without manual intervention, in equipment connected in series, substantially unexposed to the environment;