公开(公告)号：EP1534264A2

公开(公告)日：2005-06-01

申请号：EP03713729.6

申请日：2003-02-26

申请人： Sunesis Pharmaceuticals, Inc.

发明人： BARR, Kenneth ,  FAHR, Bruce ,  HANSEN, Stig ,  WIESMANN, Christian

IPC分类号： A61K31/343 ,  C07D307/80

CPC分类号： C07D405/12 ,  A61K31/343 ,  A61K31/635 ,  C07D307/80 ,  C07D417/12

摘要： The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B (“PTP-1B”). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase (“TC-PTP”). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.