公开(公告)号：EP3582815A1

公开(公告)日：2019-12-25

申请号：EP18712284.1

申请日：2018-02-16

申请人： Sunovion Pharmaceuticals Inc.

发明人： HOPKINS, Seth ,  KOBLAN, Kenneth ,  LOEBEL, Antony ,  OGIRALA, Ajay

IPC分类号： A61K45/06 ,  A61K31/381 ,  A61K31/435 ,  A61K31/55 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20 ,  C07D277/60 ,  A61P25/18

公开(公告)号：EP1509489B1

公开(公告)日：2011-07-13

申请号：EP03736639.0

申请日：2003-05-15

申请人： Sunovion Pharmaceuticals Inc.

发明人： AQUILA, Brian, A. ,  HOPKINS, Seth ,  LOCKSHIN, Curtis, A. ,  WANG, Fengjiang

IPC分类号： C07C217/58 ,  C07D307/14

CPC分类号： C40B40/04 ,  C07C217/58 ,  C07C2601/02 ,  C07D307/14 ,  C40B20/08 ,  C40B30/04 ,  C40B40/00 ,  C40B50/14

摘要： One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson’s disease, spasticity. Tourette’s syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton’s headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn’s disease, malignant gliomas, neurodegenerative diseases, Huntington’s chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.