公开(公告)号：EP4008715A1

公开(公告)日：2022-06-08

申请号：EP19940643.0

申请日：2019-12-20

申请人： Suqian Keylab Biochemical Co., Ltd.

发明人： WANG, Mingchun ,  LI, Qingyi

IPC分类号： C07D295/104 ,  C07D295/145 ,  C07D231/14 ,  A01N43/56 ,  A01P3/00

摘要： The present invention relates to a preparation method for a halogen-substituted compound, where a piperazine derivative shown in formula I reacts with a halogenated acetyl halide derivative shown in formula VI to generate a halogen-substituted compound shown in formula II. The present invention further relates to a preparation method for preparing a pyrazole derivative by using a halogen-substituted compound, where a halogen-substituted compound shown in formula II reacts with methylhydrazine to close a pyrazole ring, to generate a halogen-substituted alkyl-1-methylpyrazole derivative shown in formula IV, or reacts with methylhydrazine benzaldehyde hydrazone to generate a hydrazone compound shown in formula III, which closes, under the action of an acid, a pyrazole ring to generate a halogen-substituted alkyl-1-methylpyrazole derivative shown in formula IV The present invention further relates to a structure of an intermediate compound. The preparation methods for a halogen-substituted compound and a pyrazole derivative of the present invention are suitable for industrial production.