公开(公告)号：EP4059966A1

公开(公告)日：2022-09-21

申请号：EP19952580.9

申请日：2019-11-19

申请人： Suzhou Yi-hua Biomedical Technology Co., Ltd. ,  Suzhou Ronnsi Pharma Co., Ltd.

发明人： JIN, Yongsheng ,  DING, Xiujuan ,  CHEN, Wu ,  LI, Xiaoming ,  SUN, Junting ,  ZHU, Yihao ,  LU, Xiaohua ,  JIN, Caijuan ,  ZHOU, Hua ,  WANG, Ningxia ,  LI, Yongbao ,  ZHOU, Qiaoyun ,  QIAN, Jiangen ,  CHONG, Xi ,  YAO, Yiming ,  JIANG, Yi

IPC分类号： C08B37/00 ,  A61K31/726 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  A61P9/00

摘要： Provided is a low-molecular-weight holothurian glycosarninoglycan, with the constituent units thereof being a glucuronic acid group, an N-acetaminogalactose group and a fucose group, and a sulfate ester group or acetyl ester group thereof. Glucuronic acid and N-acetaminogalactose are interconnected via β(1-3) and β(1-4) glucosidic bonds to form a backbone of a disaccharide repeating structural unit, and a fucose group is connected to the backbone as a side chain. On a molar ratio basis, the ratio of the glucuronic acid group: the N-acetaminogalactose group: the fucose group is 1: (0.8-1.2): (0.6-1.2). In the structure of the low-molecular-weight holothurian glycosaminoglycan, 10-30 % of glucuronic acid groups are modified, on the 2-position, with a sulfate ester group, and the rest are hydroxyl groups; and a proportion of 10-30 % of fucose groups is modified, on the 2-position, with an acetyl ester group, and the rest are hydroxyl or sulfate ester groups. The low-molecular-weight holothurian glycosarninoglycan of the present invention has anti-inflammation, anti-vasculopathy, anti-tumor or anti-tumor-metastasis functions, and the effect of improving learning and memory abilities, and can be used for preparing a related drug or health-care product.