公开(公告)号：EP1781604A1

公开(公告)日：2007-05-09

申请号：EP05762347.2

申请日：2005-06-20

申请人： Synta Pharmaceuticals Corporation

发明人： KOSTIK, Elena ,  VAGHEFI, Farid ,  LIANG, Guiqing ,  KOYA, Keizo ,  SUN, Lijun ,  TATSUTA, Noriaki ,  CHEN, Shoujun ,  INOUE, Takayo ,  XIA, Zhi-Qiang

IPC分类号： C07C327/56 ,  A61K31/16 ,  A61P35/00

CPC分类号： C07D305/14 ,  C07C327/56 ,  C07C2601/02

摘要： Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is -O or -S. M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation. Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.