公开(公告)号：EP4295852A3

公开(公告)日：2024-06-12

申请号：EP23177402.7

申请日：2017-07-13

申请人： Syros Pharmaceuticals, Inc.

发明人： MARINEAU, Jason J. ,  ZAHLER, Robert ,  CIBLAT, Stephane ,  WINTER, Dana ,  KABRO, Anzhelika ,  ROY, Stephanie ,  SCHMIDT, Darby ,  CHUAQUI, Claudio ,  MALOJCIC, Goran ,  PIRAS, Henri ,  WHITMORE, Kenneth Matthew ,  LUND, Kate-lyn ,  SINKO, William ,  SPROTT, Kevin

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D401/14 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

公开(公告)号：EP3694860A1

公开(公告)日：2020-08-19

申请号：EP18793147.2

申请日：2018-10-09

申请人： Syros Pharmaceuticals, Inc.

发明人： MOEBIUS, David ,  MARINEAU, Jason J. ,  ZHANG, Yi ,  AUSTGEN, Kathryn ,  CHUAQUI, Claudio Edmundo ,  MALOJCIC, Goran ,  SINKO, William ,  GUAN, Huiping Amy ,  SAVOIE, Tracey Lodie ,  CIBLAT, Stephane ,  JAMES, Clint ,  XOLIN, Amandine ,  BERNARD, Sylvain ,  DOSHI, Malay

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61K31/53

公开(公告)号：EP4295852A2

公开(公告)日：2023-12-27

申请号：EP23177402.7

申请日：2017-07-13

申请人： Syros Pharmaceuticals, Inc.

发明人： MARINEAU, Jason J. ,  ZAHLER, Robert ,  CIBLAT, Stephane ,  WINTER, Dana ,  KABRO, Anzhelika ,  ROY, Stephanie ,  SCHMIDT, Darby ,  CHUAQUI, Claudio ,  MALOJCIC, Goran ,  PIRAS, Henri ,  WHITMORE, Kenneth Matthew ,  LUND, Kate-lyn ,  SINKO, William ,  SPROTT, Kevin

IPC分类号： A61K31/506

摘要： The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.