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    2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof
    2.
    发明公开
    2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof 失效
    2-β-取代物甲基青霉烯衍生物和盐酸盐和酯。

    公开(公告)号：EP0272016A1

    公开(公告)日：1988-06-22

    申请号：EP87310583.7

    申请日：1987-12-01

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Tanaka, Motoaki ,  Yamada, Shozo ,  Nakai, Akira ,  Ohbayashi, Hisashi ,  Ohno, Tomoyasu

    IPC分类号： C07D499/00 ,  A61K31/43

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： Disclosed are 2β-substituted-methylpenicillanic acid compounds of the formula
    wherein n is 0, 1 or 2; and -
    is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.
    These compounds are useful as β-lactamase inhibitor.

    摘要翻译： 公开了式CHEM的2个β-取代的 - 甲基青霉烷酸化合物，其中n是0,1或2; 和 - @@@@是在其环结构中具有2至4个氮原子作为杂原子的单环或双环杂环基团，其可任选被烷基，烷氧基羰基，苯基，甲酰基或任选具有烷基，硝基或 所述杂环基团不是1,2,3-三唑-1-基; 或其盐或酯。 这些化合物可用作β-内酰胺酶抑制剂。

    2Beta-substituted thiomethylpenicillin derivatives and their preparation and use
    4.
    发明公开
    2Beta-substituted thiomethylpenicillin derivatives and their preparation and use 失效
    2-β - 取代的硫代甲基Penizillinderivate和它们的制备和用途。

    公开(公告)号：EP0236074A1

    公开(公告)日：1987-09-09

    申请号：EP87301699.2

    申请日：1987-02-26

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED

    发明人： Torii, Sigeru ,  Tanaka, Hideo ,  Tanaka, Motoaki ,  Yamada, Shozo ,  Nakai, Akira ,  Ohbayashi, Hisashi

    IPC分类号： C07D499/00 ,  A61K31/43

    CPC分类号： C07D499/00

    摘要： Disclosed is a penicillin derivative of the formula:
    wherein n is an integer of 0, l or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group,
    wherein R₁ is a hydrogen atom, a lower alkyl group, a phenyl group, a group -(CH₂) m -OR₂ or -(CH₂) m COOR₂ (m is an integer of l to 6 and R₂ is a hydrogen atom or a penicillin carboxyl ester-forming group which is commonly used for penicillin derivatives) or a phenyl group substituted by at least one member selected from the class consisting of lower alkyl group, halogen atom and lower alkoxy group; and R is a hydrogen atom or a penicillin carboxyl ester-forming group, or a salt thereof. They are useful as β-lactamase inhibitors.