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1.发明公开Polyhydroxyalkanoate depolymerase and process for producing the same 失效聚羟基链烷酸解聚酶和Verfahren zu deren Herstellung
公开(公告)号：EP0863209A3
公开(公告)日：1999-12-01
申请号：EP98300131.4
申请日：1998-01-08
发明人： Saito, Yuji, c/o Taisei Corporation , Shibayama, Masako, c/o Taisei Corporation , Takebe, Hidehi, c/o Meiji Seika Kaisha, Ltd. , Matsunobu, Toshio, c/o Meiji Seika Kaisha, Ltd.
摘要： A polyhydroxyalkanoate depolymerase having a N-terminal fragment of the amino acid sequence of SEQ ID NO: 1 and having a molecular weight of about 33,000 a determined by SDS polyacrylamide gel electrophoresis, can decompose ω-hydroxyalkanoate polymers, particularly 4-hydroxybutyrate homopolyester or copolymerized polyesters containing said homopolyester.
摘要翻译： 具有SEQ ID NO：1的氨基酸序列的N-末端片段并通过SDS聚丙烯酰胺凝胶电泳测定的分子量约为33,000的聚羟基链烷酸酯解聚酶可分解ω-羟基链烷酸酯聚合物，特别是4-羟基丁酸酯均聚酯或共聚合 含有所述均聚酯的聚酯。
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公开(公告)号：EP0863209A2
公开(公告)日：1998-09-09
申请号：EP98300131.4
申请日：1998-01-08
发明人： Saito, Yuji, c/o Taisei Corporation , Shibayama, Masako, c/o Taisei Corporation , Takebe, Hidehi, c/o Meiji Seika Kaisha, Ltd. , Matsunobu, Toshio, c/o Meiji Seika Kaisha, Ltd.
摘要： A polyhydroxyalkanoate depolymerase having a N-terminal fragment of the amino acid sequence of SEQ ID NO: 1 and having a molecular weight of about 33,000 a determined by SDS polyacrylamide gel electrophoresis, can decompose ω-hydroxyalkanoate polymers, particularly 4-hydroxybutyrate homopolyester or copolymerized polyesters containing said homopolyester.
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3.发明公开Sustained-release pharmaceutical composition 审中-公开Pharmazutische Zusammensetzung mitverzögerteFreisetzung
公开(公告)号：EP0945137A1
公开(公告)日：1999-09-29
申请号：EP99250005.8
申请日：1999-01-11
发明人： Ueno, Shinobu, c/o Meiji Seika Kaisha Ltd. , Kawashima, Junichi, c/o Meiji Seika Kaisha Ltd. , Iinuma, Katsuharu, c/o Meiji Seika Kaisha Ltd. , Tomosawa, Takashi, c/o Taisei Corporation , Saito, Yuji, c/o Taisei Corporation , Shibayama, Masako, c/o Taisei Corporation
CPC分类号： A61K47/34 , A61K9/7007
摘要： The present invention relates to a sustained-release pharmaceutical composition comprising a hydroxyalkanoic acid copolymer consisting of a 3-hydroxybutyric acid unit and a 4-hydroxybutyric acid unit, and a biologically active substance. The sustained-release pharmaceutical composition of the present invention can regulate the degree of release of a biologically active agent easily by changing the ratio of the 3-hydroxybutyric acid (3HB) component to the 4-hydroxybutyric acid (4HB) component in P(3HB-co-4HB) as a basic substance and by changing the thickness of its sheet.
摘要翻译： 本发明涉及包含由3-羟基丁酸单元和4-羟基丁酸单元组成的羟基链烷酸共聚物和生物活性物质的缓释药物组合物。 本发明的缓释药物组合物可以通过改变P（3HB）中3-羟基丁酸（3HB）组分与4-羟基丁酸（4HB）组分的比例，容易地调节生物活性剂的释放度 -co-4HB）作为碱性物质，并通过改变其片材的厚度。
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