公开(公告)号：EP3173408A4

公开(公告)日：2017-12-06

申请号：EP15825310

申请日：2015-07-24

申请人： TAISHO PHARMA CO LTD

发明人： KURODA SHOICHI ,  KAWABE KENICHI ,  USHIKI YASUNOBU ,  OHTA HIROSHI ,  UNEUCHI FUMITO ,  SHIBATA TSUYOSHI ,  TABUSE HIDEAKI ,  MUNETOMO EIJI ,  CHONAN SUMI

IPC分类号： C07D401/10 ,  A61K31/4725 ,  A61P1/10 ,  A61P13/12 ,  A61P19/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D405/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10

CPC分类号： C07D417/10 ,  A61K31/4725 ,  C07D401/10 ,  C07D401/14 ,  C07D403/14 ,  C07D405/10 ,  C07D413/10 ,  C07D413/14

摘要： The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ[Formula 15]€ƒ€ƒ€ƒ€ƒ€ƒA-Y [1] wherein A represents a structure represented by the following formula [2]: wherein R 11 and R 12 each represent a halogen atom or the like, R 2 represents C 1-6 alkyl or the like, ring E represents triazole, tetrazole, pyrimidine, or the like, R 31 and R 32 each represent a hydrogen atom, C 1-6 alkyl, C 1-6 alkoxy, or the like, and W represents a single bond, the formula -NH-, the formula -O-, or the formula -CONH-, and Y represents a hydrogen atom or a structure represented by the following formula [3']: