-
公开(公告)号：EP0067008A1
公开(公告)日：1982-12-15
申请号：EP82302681.0
申请日：1982-05-25
发明人： Amano, Takehiro , Ogawa, Toshihisa , Yoshikawa, Kensei , Shiobara, Yoshinori , Sano, Tatsuhiko , Ito, Shoichi , Ohuchi, Yutaka , Sawada, Jiro , Tanami, Tohru
IPC分类号： C07C69/618 , C07D307/12 , A61K31/215 , A61K31/34
CPC分类号： C07D307/12
摘要： A novel carboxylic acid ester having the following general formula
wherein R is alkoxyalkyl having 2 to 6 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, tetrahydrofurfuryl, alkyl having 1 to 6 carbon atoms or said alkyl substituted with 1 or 2 hydroxyl groups, is a useful anti-inflammatory and analgesic agent.摘要翻译： 具有下列通式的新型羧酸酯，其中R为具有2至6个碳原子的烷氧基烷基，具有5或6个碳原子的环烷基，四氢糠基，具有1至6个碳原子的烷基或所述被1或2个羟基取代的烷基， 一种有用的抗炎和镇痛剂。
-
公开(公告)号：EP0196910A2
公开(公告)日：1986-10-08
申请号：EP86302395.8
申请日：1986-04-01
发明人： Migita, Yoshihiro , Eguchi, Tadashi , Kumazawa, Yukinari , Nakagami, Jozi , Amano, Takehiro , Sota, Kaoru , Sakakibara, Jinsaku
IPC分类号： C07D241/38 , A61K31/495
CPC分类号： C07D241/38
摘要： Novel benzo[a]phenazine derivatives of the formula
wherein R 1 is hydrogen, halogen, methyl, hydroxyl or alkoxy, R 2 is -COO R S (wherein R 5 is hydrogen, straight or branched chain alkyl, cycloalkyl having 3 - 6 carbon atoms, benzyl or phenyl) or - CON R 6 (wherein R 6 and R 7 are the same or R 7 different and are each hydrogen or lower alkyl, or R 6 and R7 together with the nitrogen atom to which they are attached form pyrrolidine or piperidine), R 3 and R 4 are the same or different and are each hydrogen or lower alkyl, and n is an integer of 2 or 3, and the salts thereof are disclosed. These compounds have antitumor activity in mammals.-
公开(公告)号：EP0073447B1
公开(公告)日：1984-11-21
申请号：EP82107715.3
申请日：1982-08-23
-
公开(公告)号：EP0067569B1
公开(公告)日：1985-02-20
申请号：EP82302682.8
申请日：1982-05-25
发明人： Takano, Seiichi , Otomo, Susumu , Amano, Takehiro
IPC分类号： C07D277/06 , C07D417/06 , A61K31/425
CPC分类号： C07D277/06
-
公开(公告)号：EP0073447A1
公开(公告)日：1983-03-09
申请号：EP82107715.3
申请日：1982-08-23
发明人： Amano, Takehiro , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ishiguro, Michihiro , Shiono, Manzo , Fujita, Yoshiji , Nishida, Takashi
摘要： A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100°C and 150°C to form a Grignard reagent, and then reacting it with acetaldehyde.
-
-
公开(公告)号：EP0342990A3
公开(公告)日：1991-09-18
申请号：EP89305066.6
申请日：1989-05-18
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： A process for preparing erythromycin A oxime or a salt thereof comprises reacting erythromycin A with hydroxylamine using an acid. Erythromycin A oxime and the salts thereof are useful as intermediates for the synthesis of macrolide antibiotics.
-
8.发明公开Process for preparing erythromycin A oxime or a salt therof 失效Verfahren zur Herstellung von Erythromcin A-oxim oder eines Salzes davon。
公开(公告)号：EP0342990A2
公开(公告)日：1989-11-23
申请号：EP89305066.6
申请日：1989-05-18
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： A process for preparing erythromycin A oxime or a salt thereof comprises reacting erythromycin A with hydroxylamine using an acid. Erythromycin A oxime and the salts thereof are useful as intermediates for the synthesis of macrolide antibiotics.
摘要翻译： 制备红霉素A肟或其盐的方法包括使用酸将红霉素A与羟胺反应。 红霉素A肟及其盐可用作合成大环内酯类抗生素的中间体。
-
公开(公告)号：EP0196910A3
公开(公告)日：1987-09-02
申请号：EP86302395
申请日：1986-04-01
发明人： Migita, Yoshihiro , Eguchi, Tadashi , Kumazawa, Yukinari , Nakagami, Jozi , Amano, Takehiro , Sota, Kaoru , Sakakibara, Jinsaku
IPC分类号： C07D241/38 , A61K31/495
CPC分类号： C07D241/38
摘要： Novel benzo[a]phenazine derivatives of the formula
wherein R 1 is hydrogen, halogen, methyl, hydroxyl or alkoxy, R 2 is -COO R S (wherein R 5 is hydrogen, straight or branched chain alkyl, cycloalkyl having 3 - 6 carbon atoms, benzyl or phenyl) or - CON R 6 (wherein R 6 and R 7 are the same or R 7 different and are each hydrogen or lower alkyl, or R 6 and R7 together with the nitrogen atom to which they are attached form pyrrolidine or piperidine), R 3 and R 4 are the same or different and are each hydrogen or lower alkyl, and n is an integer of 2 or 3, and the salts thereof are disclosed. These compounds have antitumor activity in mammals.-
公开(公告)号：EP0074008A2
公开(公告)日：1983-03-16
申请号：EP82107714.6
申请日：1982-08-23
发明人： Amano, Takehiro , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ishiguro, Michihiro , Shiono, Manzo , Fujita, Yoshiji , Nishida, Takashi
IPC分类号： C07C69/612 , C07C67/343 , C07C69/736 , C07C69/65 , C07C69/618 , C07D207/20 , C07D235/02 , C07D491/052 , C07D333/08 , C07D263/58
CPC分类号： C07D263/57 , C07C57/30 , C07C57/42 , C07D207/20 , C07D333/24 , C07D471/04 , C07D491/04
摘要： A process for producing an a-arylalkanoic acid ester represented by the general formula
wherein Ar represents an aryl group which may optionally be substituted, and R' and R 2 , independently from each other, represents a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula
wherein Ar is as defined above and X 1 represents a halogen atom, and magnesium, with an a-haloalkanoic acid ester of the general formula
wherein R' and R 2 are as defined above, and X 2 represents a halogen atom, said reaction of the Grignard reagent with the a-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.009 秒)
