公开(公告)号：EP0795545A1

公开(公告)日：1997-09-17

申请号：EP95937181.6

申请日：1995-11-27

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： SHIRAI, Hirofusa ,  HANABUSA, Kenji ,  TAKAHASHI, Yuki Taisho Pharmaceutical Co., Ltd. ,  MIZOBE, Fumio Taisho Pharmaceutical Co., Ltd. ,  HANADA, Kazunori Taisho Pharmaceutical Co., Ltd.

IPC分类号： C07D213/55 ,  C07D213/56 ,  C07D213/40 ,  A61K31/44

CPC分类号： C07D213/40 ,  C07D213/38 ,  C07D213/55 ,  C07D213/56

摘要： A pyridine derivative represented by the following formula:
, where R 1 is a methyl group or a functional group represented by any one of the following formulae:

        ―CONHCH 2 CH 2 N(CH 3 ) 2



        ―CONHCH 2 CH 2 CH 2 N(CH 3 ) 2



        ―COOCH 2 CH 2 N(CH 3 ) 2



        ―COOCH 2 CH 2 N(CH 2 CH 3 ) 2



        ―NHCOCH 2 N(CH 3 ) 2



        ―NHCOCH 2 N(CH 2 CH 3 ) 2

and R 2 is a hydrogen atom, an amino group or a functional group represented by any one of the following formulae:

        ―CONHCH 2 CH 2 N(CH 3 ) 2




        ―COOCH 2 CH 2 N(CH 3 ) 2



        ―NHCOCH 2 N(CH 3 ) 2



        ―NHCOCH 2 N(CH 2 CH 3 ) 2

or a salt thereof directly or indirectly acts on neuronal cells in vivo and is expected to show an effect on amelioration and curing of nerve disorders due to neuronal degeneration, with application as a drug for ameliorating and curing, for example, traumatic symptoms and maladies, those induced by drugs such as alcohol, antineoplastic agents, etc., inflammatory ones, metabolic ones as observed in diabetes, etc., and furthermore those due to idiopathic degeneration of peripheral nerves, and also with application as drugs for ameliorating and curing symptoms and maladies due to degeneration of central nerves, for example, Alzheimer's disease and cerebrovascular ischemia, Down syndrome, Parkinson's disease, Huntington chorea, diseases secondary to cerebral ischemia, cerebral infarction, intracerebral bleeding, head injuries, etc., amnesia, spinal neuropathy, etc.

摘要翻译： 由下式表示的吡啶衍生物：，其中R 1是由下式中的任一个表示的甲基或官能团：-CONHCH 2 CH 2 N（CH 3）2 -CONHCH 2 CH 2 CH 2 N（CH 3）2 -COOCH 2 CH 2 N（CH 3） CH 3）2 -COOCH 2 CH 2 N（CH 2 CH 3）2 -NHCOCH 2 N（CH 3）2 -NHCOCH 2 N（CH 2 CH 3）2和R 2是由下式表示的氢原子，氨基或官能团：-CONHCH2CH2N（ CH3）2 -COOCH2CH2N（CH3）2 -NHCOCH2N（CH3）2 -NHCOCH2N（CH2CH3）2或其盐在体内直接或间接作用于神经元细胞，预计会显示出对神经的改善和治愈的作用 由于神经元变性引起的疾病，作为改善和治愈的药物，例如外伤性症状和疾病，由诸如酒精，抗肿瘤药物等药物引起的疾病，炎性炎症，糖尿病中观察到的代谢性疾病等。 ，而且由于周围神经的特发性退化，以及应用a 用于改善和治疗由于中枢神经变性引起的症状和疾病的药物，例如阿尔茨海默病和脑血管缺血，唐氏综合症，帕金森氏症，亨廷顿舞蹈病，脑缺血继发性疾病，脑梗死，脑内出血，头部损伤等 遗忘症，脊髓神经病变等