公开(公告)号：EP0553353A1

公开(公告)日：1993-08-04

申请号：EP91917071.2

申请日：1991-10-08

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： ASAKA, Toshifumi ,  MISAWA, Yoko ,  KASHIMURA, Masato ,  MORIMOTO, Shigeo ,  WATANABE, Yoshiaki ,  HATAYAMA, Katsuo

IPC分类号： C07H17/08 ,  A61K31/71

CPC分类号： C07H17/08

摘要： Modified erythromycin having remarkably alleviated bitterness and improved bioabsorbability, comprising a compound prepared by introducing a group represented by the formula: -O-CO-O-[(CH₂) m -O] n -R (wherein R represents C₁ to C₁₂ alkyl, m represents an integer of 2 to 4, and n represents an integer of 1 to 7), into the 2'-position of an erythromycin, or its salt.

摘要翻译： 改进的红霉素具有显着缓解的苦味和改善的生物吸收性，包括通过引入由下式表示的基团制备的化合物：-O-CO-O - [（CH2）mO] nR（其中R表示C1至C12烷基，m表示整数 2〜4，n表示1〜7的整数），进入红霉素或其盐的2'-位。