公开(公告)号：EP0666253A1

公开(公告)日：1995-08-09

申请号：EP93923036.3

申请日：1993-10-20

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  MITSUI PETROCHEMICAL INDUSTRIES, LTD.

发明人： MIYOSHI, Toshio, Taisho Pharmaceutical Co., Ltd. ,  ASAMI, Yumiko, Taisho Pharmaceutical Co., Ltd. ,  SATO, Masakazu, Taisho Pharmaceutical Co., Ltd. ,  ISHIGURO, Masaharu, Mitsui Petrochemical Ind., Ltd ,  KITAHARA, Takumi, Mitsui Petrochemical Ind., Ltd. ,  TOMINO, Ikuo, Mitsui Petrochemical Ind., Ltd.

IPC分类号： C07C317/36 ,  C07C317/40 ,  C07C323/37 ,  C07C323/41 ,  A61K31/135 ,  A61K31/14 ,  A61K31/16

CPC分类号： C07C323/37 ,  C07C317/36 ,  C07C323/41

摘要： An N-t-butylaniline analog represented by general formula (I) or a salt thereof, and a lipid level depressant containing the same as the active ingredient. In said formula, R¹ and R², which may be the same or different from each other, represent each hydrogen, halogen, amino, nitro, acetamide, lower alkyl, lower alkoxy, halogenated lower alkyl, halogenated lower alkoxy or lower alkanoyl; R³ represents hydrogen, halogen, lower alkoxy or halogenated lower alkyl; and Z represents S, SO or SO₂. This compound has a remarkably excellent effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely reduced in toxicity.

摘要翻译： 由通式（I）表示的N-叔丁基苯胺类似物或其盐，以及含有与活性成分相同的脂质降低剂。 在所述式中，R 1和R 2可以彼此相同或不同，表示氢，卤素，氨基，硝基，乙酰胺，低级烷基，低级烷氧基，卤代低级烷基，卤代低级烷氧基 或低级烷酰基; R 3表示氢，卤素，低级烷氧基或卤代低级烷基; Z表示S，SO或SO 2。 与氯贝特和4-（N-叔丁基）甲磺酰氨基二苯醚相比，该化合物具有显着优异的抑制脂质水平的作用，毒性极度降低。