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    Sulfonamide derivatives
    1.
    发明公开
    Sulfonamide derivatives 失效
    磺酰胺衍生物

    公开(公告)号：EP0469901A1

    公开(公告)日：1992-02-05

    申请号：EP91307061.1

    申请日：1991-08-01

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  NIPPON SUISAN KAISHA, LTD.

    发明人： Sato, Masakazu ,  Kawashima, Yutaka ,  Goto, Jun ,  Chiba, Yoshiyuki ,  Satake, Mikio ,  Iwata, Chuzo ,  Imanishi, Takeshi

    IPC分类号： C07C323/49 ,  C07C317/28 ,  C07C317/44 ,  C07C323/20 ,  C07D213/71 ,  A61K31/18

    CPC分类号： C07C317/44 ,  C07C317/28 ,  C07C323/49 ,  C07C323/62 ,  C07D213/71

    摘要： Sulfonamide derivative, useful as blood platelet aggregation inhibitors, have the formula:

    in which A is a naphthyl group, a pyridyl group, a phenyl group, a phenyl group substituted by 1 to 5 substituents selected from halogen atoms, alkyl groups having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, nitro groups and acetamido groups, or an alkyl group having 1 to 20 carbon atoms; B is an alkylene group having 1 to 3 carbon atoms, a group -OCH₂- or a group -CH=CH-; X and Y are the same or different, and each is a hydrogen or fluorine atom; R is a carboxy group, an alkyoxycarbonyl group having 2 to 5 carbon atoms, a hydroxymethyl group or a group of the formula
    (in which R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R² is a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 3 carbon atoms, a carboxymethyl group or an alkoycarbonylmethyl group having 3 to 6 carbon atoms); m is 0, 1 or 2; n is 0,1,2 or 3; or salts thereof.
    This invention also provided intermediates for the preparation of the sulfonamide, which intermediates are thiophenols of the formula:

    (in which R, X and Y are as defined above).

    摘要翻译： 可用作血小板聚集抑制剂的磺酰胺衍生物具有下式：其中A是萘基，吡啶基，苯基，被1至5个选自卤素原子的取代基取代的苯基，具有1至4个碳原子的烷基 碳原子，具有1至4个碳原子的烷氧基，硝基和乙酰氨基，或具有1至20个碳原子的烷基; B是具有1-3个碳原子的亚烷基，基团-OCH 2 - 或基团-CH = CH-; X和Y相同或不同，并且各自是氢或氟原子; R为羧基，具有2至5个碳原子的烷氧基羰基，羟甲基或下式基团（其中R 1为氢原子或具有1至3个碳原子的烷基; R 2为氢原子， 羟基，碳原子数为1〜3的烷基，羧甲基或碳原子数为3〜6的烷基羰甲基）。 m是0,1或2; n是0,1,2或3; 或其盐。 本发明还提供了用于制备磺酰胺的中间体，其中间体是下式的苯硫酚:(其中R，X和Y如上所定义）。

    Triazole derivatives
    3.
    发明公开
    Triazole derivatives 失效
    三唑衍。

    公开(公告)号：EP0381439A1

    公开(公告)日：1990-08-08

    申请号：EP90300945.4

    申请日：1990-01-30

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  NIPPON SUISAN KAISHA, LTD.

    发明人： Iwata, Chuzo ,  Imanishi, Takeshi ,  Chiba, Yoshiyuki ,  Satake, Mikio ,  Sato, Masakazu ,  Kawashima, Yutaka ,  Goto, Jun

    IPC分类号： C07D249/14 ,  A61K31/41

    CPC分类号： C07D249/14

    摘要： Triazole derivatices useful as lipid peroxidation inhibitors have the formula:
    in which R¹ is a hydrogen atom, a C₁-C₄ alkyl group, an acetyl group, a naphthylmethyl group, an anthrylmethyl group or a group of the formula
    (in which X, Y and Z are the same or different and each is a hydrogen or halogen atom, a C₁-C₄ alkyl group, a C₁-C₄ alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a cyano group or a benzyloxy group); R² is a hydrogen atom or an acetyl group; and R³ is a hydrogen atom, an acetyl group or a group of the formula
    (in which R¹ and R² have the meanings defined above).

    摘要翻译： 可用作脂质过氧化抑制剂的三唑衍生物具有下式：其中R 1是氢原子，C 1 -C 4烷基，乙酰基，萘基甲基，蒽基甲基或式 CHEM>（其中X，Y和Z相同或不同，各自为氢或卤素原子，C1-C4烷基，C1-C4烷氧基，羟基，硝基，三氟甲基， 氰基或苄氧基）; R 2是氢原子或乙酰基; 和R 3是氢原子，乙酰基或式CHEM的基团（其中R 1和R 2具有上述定义）。 一个