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    Process for producing cytotoxic lymphocytes
    3.
    发明公开
    Process for producing cytotoxic lymphocytes 有权
    产生细胞毒性淋巴细胞的方法

    公开(公告)号：EP2305796A1

    公开(公告)日：2011-04-06

    申请号：EP10184353.0

    申请日：2003-03-25

    申请人： TAKARA BIO INC.

    发明人： Sagawa, Hiroaki ,  Ideno, Mitsuko ,  Kato, Ikunoshin

    IPC分类号： C12N5/0783 ,  A61K35/14

    CPC分类号： C12N5/0638 ,  A61K2035/124 ,  C12N5/0636 ,  C12N2501/58 ,  C12N2510/00

    摘要： The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.

    摘要翻译： 本发明涉及制备细胞毒性淋巴细胞的方法，其特征在于该方法包括在纤连蛋白，其片段或其混合物存在下进行细胞毒性淋巴细胞的诱导，维持和扩增中的至少一种的步骤。

    Method of extended culture of antigen-specific cyotoxic T lymphocytes
    6.
    发明公开
    Method of extended culture of antigen-specific cyotoxic T lymphocytes 审中-公开
    Verfahren zur verb desserten Kultur von antigenspezifischen zyotoxischen T-Lymphozyten

    公开(公告)号：EP2070542A2

    公开(公告)日：2009-06-17

    申请号：EP09004189.8

    申请日：2002-08-15

    申请人： TAKARA BIO INC.

    发明人： Sagawa, Hiroaki ,  Ideno, Mitsuko ,  Kato, Ikunoshin

    IPC分类号： A61K35/14 ,  C12N5/08

    CPC分类号： C12N5/0636 ,  A61K2039/515 ,  A61K2039/5158 ,  C12N2501/105 ,  C12N2501/12 ,  C12N2501/23 ,  C12N2501/515 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/905

    摘要： The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.

    摘要翻译： 本发明是诱导具有抗原特异性细胞毒活性的细胞毒性T细胞的方法，用于维持细胞的方法，连续培养细胞的方法或扩增细胞的方法，包括培养细胞毒性T细胞的步骤 在至少一种选自（A）与CD44具有结合活性的物质的物质的存在下， （B）能够调节通过将CD44配体结合到CD44而发射的信号的物质; （C）能够抑制生长因子与生长因子受体结合的物质; （D）能够调节由生长因子与生长因子受体结合而发出的信号的物质; 和（E）纤连蛋白，其片段或其混合物。