公开(公告)号：EP1020429B1

公开(公告)日：2006-07-12

申请号：EP98941825.6

申请日：1998-09-11

申请人： TAKARA BIO INC.

发明人： TAKESAKO, Kazutoh ,  KUROME, Toru ,  AWAZU, Naoyuki ,  KATO, Ikunoshin

IPC分类号： C07C219/06 ,  C07C229/06 ,  C07C235/12 ,  A61K31/16 ,  A61K31/22

CPC分类号： C07C219/06 ,  C07C229/08 ,  C07C235/12 ,  C07C237/12 ,  C07C237/22

摘要： Sphingosine derivatives capable of regulating the function of sphingolipids. The sphingosine derivatives are represented by general formula (I) wherein R and R are the same or different and each represents hydrogen, C1-4 alkyl, or C2-5 acyl; R and R are the same or different and each represents hydrogen or hydroxyl, or R and R in combination represent a covalent bond; and X represents -(CH2)n-CO-NH-CH(R )-R or-(CH2)m-O-CO-CH(R )-R .

公开(公告)号：EP1002790B1

公开(公告)日：2005-12-28

申请号：EP98907195.6

申请日：1998-03-12

申请人： TAKARA BIO INC.

发明人： TAKESAKO, Kazutoh ,  KUROME, Toru ,  AWAZU, Naoyuki ,  KATO, Ikunoshin

IPC分类号： C07C215/10 ,  C07C229/22 ,  C07C271/22 ,  C07C215/24 ,  C07C229/30 ,  C07D263/06

CPC分类号： C07D307/33 ,  C07C215/10 ,  C07C215/24 ,  C07C229/22 ,  C07C229/30 ,  C07C237/08 ,  C07C237/22 ,  C07C251/08 ,  C07C271/22 ,  C07D263/06 ,  Y02P20/55

摘要： Novel sphingosine analogues useful as intermediates for the synthesis of novel lipid derivatives such as sphingolipid derivatives controlling the function of sphingolipid. The sphingosine analogues are represented by general formula (I), wherein Q?1 and Q2¿ are each independently hydrogen, C¿1?-C4 alkyl, C2-C5 acyl or an amino-protecting group and Q?3¿ is hydrogen or a hydroxyl-protecting group, or alternatively Q?2 and Q3¿ are united to form isopropylidene and Q1 is hydrogen or an amino-protecting group; Q?4 and Q5¿ are each independently hydroxyl, C¿2?-C5 acyl, -O-Q?6¿ or hydrogen, or alternatively Q?4 and Q5¿ may be united to form a covalent bond; Q6 is a hydroxyl-protecting group; X1 is -COOH, -CONH¿2?, -CO-Q?7, -CH¿2OH or -CH2O-Q8; Q7 is a carboxyl-protecting group; and Q8 is a hydroxyl-protecting group.

摘要翻译： 可用作合成新的脂质衍生物的中间体的新型鞘氨醇类似物，例如控制鞘脂的功能的鞘脂衍生物。 鞘氨醇类似物由通式（I）表示，其中Q 1和Q 2各自独立地是氢，C 1 -C 4烷基，C 2 -C 5酰基或氨基保护基，Q 3是氢或 羟基保护基，或者Q 2和Q 3结合形成异亚丙基，Q1是氢或氨基保护基; Q 4和Q 5各自独立地为羟基，C 2 -C 5酰基，-O-Q 6或氢，或者Q 4和Q 5可以结合形成共价键; Q6是羟基保护基; X 1是-COOH，-CONH 2，-CO-Q 7，-CH 2 OH或-CH 2 O-Q 8; Q7是羧基保护基; Q8是羟基保护基。