公开(公告)号：EP1227081A4

公开(公告)日：2004-08-11

申请号：EP00970080

申请日：2000-10-26

申请人： TAKEDA CHEMICAL INDUSTRIES LTD

发明人： YAMANE TAIHEI ,  INAGAKI ATSUSHI ,  YABE OSAMU

IPC分类号： A61K31/195 ,  A61K31/421 ,  A61P3/10 ,  C07C249/12 ,  C07D263/32

CPC分类号： A61K31/195 ,  A61K31/421 ,  C07C249/12 ,  C07D263/32

摘要： A process for the preparation of compounds of general formula (III) or salts thereof wherein R1 is a heterocyclic group or the like; X is -CO- or the like; n is 1 to 3; Y is oxygen or the like; A is a benzene ring or the like; p is 1 to 8; R2 is a heterocyclic group or the like; q is 0 to 6; m is 0 or 1; R?4 and R5¿ are each a hydrocarbon group or the like; or alternatively R?4 and R2¿ may be united to form a ring), characterized by reacting a compound of general formula (I) or a salt thereof (wherein Z is halogeno or the like) with a compound of the general formula (II) or a salt thereof in an amide in the presence of a metal alkoxide.