公开(公告)号：EP1537846A1

公开(公告)日：2005-06-08

申请号：EP03795361.9

申请日：2003-09-10

申请人： TANABE SEIYAKU CO., LTD.

发明人： SUZUKI, Akira c/o Tanabe Seiyaku Co., Ltd. ,  TANIMOTO, Masahiko ,  MURATA, Junichi

IPC分类号： A61J3/02

CPC分类号： B01J13/04 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/19

摘要： In the method for preparation of microspheres by in-water drying method, an iterative process is employed, which comprises emulsifying a medicament-containing polymer solution (4) containing an organic solvent in an emulsifying device (1) to form an emulsion; transferring this emulsion into a microsphere storage tank (2); introducing a part of said emulsion to a cross flow filter (3) from the microsphere storage tank; and returning a liquid passing over the cross flow filter to the microsphere storage tank (2). Since a small amount of microsphere is repeatedly produced, this process permits the downsizing and airtight closing of an apparatus therefor, and further makes it possible to freely control the production scale of microsphere.

摘要翻译： 在通过水中干燥法制备微球的方法中，采用迭代方法，其包括在乳化装置（1）中乳化含有有机溶剂的含药聚合物溶液（4）以形成乳液; 将该乳液转移到微球储存罐（2）中; 将一部分所述乳液从微球储存罐引入交叉流过滤器（3）; 并将通过所述交叉流过滤器的液体返回到所述微球储存罐（2）。 由于反复产生少量的微球，所以该方法允许其装置的小型化和气密封闭，并且还可以自由地控制微球的生产规模。