公开(公告)号：EP2419424A2

公开(公告)日：2012-02-22

申请号：EP10764789.3

申请日：2010-02-09

申请人： Telik, Inc.

发明人： BEROZA, Paul, P. ,  DAMODARAN, Komath, V. ,  LUI, Stella ,  MA, Wenli ,  WANG, Zhuo ,  XU, Hua

IPC分类号： C07D409/10 ,  C07D333/10 ,  C07D409/12 ,  A61K31/381 ,  A61P35/00

CPC分类号： A61K31/381 ,  C07D333/38 ,  C07D409/12

摘要： Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.

公开(公告)号：EP1562564A2

公开(公告)日：2005-08-17

申请号：EP03783388.6

申请日：2003-11-14

申请人： TELIK, INC.

发明人： XU, Hua ,  BROWN, Gail, L. ,  SCHOW, Steven, R. ,  KECK, James, G.

IPC分类号： A61K31/00

CPC分类号： A61K45/06 ,  A61K31/282 ,  A61K31/337 ,  A61K31/475 ,  A61K31/5377 ,  A61K31/70 ,  A61K38/05 ,  A61K2300/00

摘要： A method of combination cancer therapy in a mammal, especially a human, by administering a therapeutically effective amount of a GST-activated anticancer compound and a therapeutically effective dose of another anticancer therapy. Pharmaceutical compositions, products, and kits for the method. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. A method of potentiating an anticancer therapy in a mammal, especially a human, comprising administering a therapeutically effective amount of a GST-activated anticancer compound to the mammal being treated with the anticancer therapy. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. The GST-activated anticancer compound is preferably a compound of US Patent No. 5,556,942, and more preferably TLK286, especially as the hydrochloride salt.