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    Stable Pharmaceutical Compositions Containing 7-Substituted-3,5-Dihydroxyheptanoic Acids or 7-Substituted-3,5-Dihydroxyheptenoic Acids
    2.
    发明公开
    Stable Pharmaceutical Compositions Containing 7-Substituted-3,5-Dihydroxyheptanoic Acids or 7-Substituted-3,5-Dihydroxyheptenoic Acids 有权
    7-取代-3,5-Dihydroxyheptansäuren或稳定的药物组合物7取代的-3,5- dihydroxyheptenoic

    公开(公告)号：EP2382970A1

    公开(公告)日：2011-11-02

    申请号：EP11171296.4

    申请日：2001-04-09

    申请人： TEVA PHARMACEUTICAL INDUSTRIES, LTD.

    发明人： Fox, Michael ,  Dorossiev, Ivo

    IPC分类号： A61K9/20 ,  A61K9/26 ,  A61K9/14 ,  A61K9/48 ,  A61K31/22 ,  A61K31/40

    CPC分类号： A61K31/40 ,  A61K9/2027 ,  A61K31/22

    摘要： Pharmaceutical compositions that have excellent storage even though they include an active component that is susceptible to degradation in an acidic environment are disclosed. The stabilized pharmaceutical composition of the invention includes a ring-opened 7-substituted-,35-dihydroxyheptanoic or a ring opened 7-substituted-3,5-dihydroxyheptenoic acid, or a pharmaceutically acceptable salt thereof, as an component and a stabilizing effective amount of at least one amino-group containing polymeric compound or at least one amino-group containing polymeric compound, or combination thereof; wherein the stabilized pharmaceutical composition does not contain a stabilizing effective amount of another stabilizer of a combination of other stabilizers. The pharmaceutical composition may optionally include one or more pharmaceutically acceptable excipients such as a filler, a disintegrating agent and one or more lubricants such as magnesium stearate to aid compression where a tablet dosage form is desired.

    摘要翻译： 药物组合物thathave优异的存储，即使它们包括活性成分做了易于降解在酸性环境中是游离缺失盘。 本发明的稳定化药物组合物包括开环的7 - 取代，35 dihydroxyheptanoic或开环的7- substituiertem -3,5- dihydroxyheptenoic酸，或其药学上可接受的盐，如与组分和稳定有效量 的含聚合化合物或至少一个的至少一个氨基的含聚合化合物，或它们的组合的氨基的基团; worin稳定化药物组合物不含有稳定有效量的其他稳定剂的组合的另一种稳定剂。 药物组合物可以任选地包括一种或多种药学上可接受的赋形剂：如填料，崩解剂和一种或多种润滑剂：如硬脂酸镁，以帮助压缩其中片剂剂型是理想的。

    Stable formulation comprising a moisture sensitive drug and manufacturing procedure thereof
    4.
    发明公开
    Stable formulation comprising a moisture sensitive drug and manufacturing procedure thereof 有权
    含用于制备制备feuchtigkeitsemphindliche活性物质和工艺稳定制备。

    公开(公告)号：EP1864677A1

    公开(公告)日：2007-12-12

    申请号：EP06252877.3

    申请日：2006-06-02

    申请人： Teva Pharmaceutical Industries Ltd

    发明人： Fox, Michael

    IPC分类号： A61K38/55 ,  A61K9/20 ,  A61K31/395 ,  A61K31/33

    CPC分类号： A61K31/33 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/395

    摘要： The present invention provides stable pharmaceutical compositions comprising moisture sensitive drugs, in particular an angiotensin converting enzyme (ACE) inhibitor such as cilazapril, as the active ingredient, and a first pharmaceutical excipient, wherein the active pharmaceutical ingredient is wet granulated with a solution of the first pharmaceutical excipient, and methods for preparing such stable pharmaceutical compositions.

    摘要翻译： 本发明提供了稳定的药物组合物，包含湿敏性药物，特别是血管紧张素转化酶（ACE）抑制剂：如西拉普利，作为活性成分，以及第一药物赋形剂，worin所述活性药物成分是湿制粒的溶液 第一药用辅料，并准备寻求稳定的药物组合物的方法。

    Stable formulation comprising a moisture sensitive drug and manufacturing procedure thereof
    5.
    发明公开
    Stable formulation comprising a moisture sensitive drug and manufacturing procedure thereof 审中-公开
    用水分敏感性药物及其制造方法稳定的制剂

    公开(公告)号：EP1917973A1

    公开(公告)日：2008-05-07

    申请号：EP07025192.1

    申请日：2006-06-02

    申请人： Teva Pharmaceutical Industries Ltd

    发明人： Fox, Michael

    IPC分类号： A61K38/55 ,  A61K9/20 ,  A61K31/395 ,  A61K31/33

    CPC分类号： A61K31/33 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/395

    摘要： The present invention provides stable pharmaceutical compositions comprising moisture sensitive drugs, in particular an angiotensin converting enzyme (ACE) inhibitor such as cilazapril, as the active ingredient, and a first pharmaceutical excipient, wherein the active pharmaceutical ingredient is wet granulated with a solution of the first pharmaceutical excipient, and methods for preparing such stable pharmaceutical compositions.

    摘要翻译： 本发明提供了稳定的药物组合物，包含湿敏性药物，特别是血管紧张素转化酶（ACE）抑制剂：如西拉普利，作为活性成分，以及第一药物赋形剂，worin所述活性药物成分是湿制粒的溶液 第一药用辅料，并准备寻求稳定的药物组合物的方法。