专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES" OR "GENVEC, INC.") AND inv:"KONG, Wing-Pui" 第 1 页

1.

发明公开
METHOD OF USING ADENOVIRAL VECTORS TO INDUCE AN IMMUNE RESPONSE 审中-公开
标题翻译：腺病毒载体的用于产生免疫应答的用途

公开(公告)号：EP1737885A2

公开(公告)日：2007-01-03

申请号：EP05778761.6

申请日：2005-04-12

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GENVEC, INC.

发明人： NABEL, Gary, J. , CHENG, Cheng , KONG, Wing-Pui , GALL, Jason, G., D. , KING, C., Richter

IPC分类号： C07K14/16

CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.