公开(公告)号：EP1551292A2

公开(公告)日：2005-07-13

申请号：EP03756863.1

申请日：2003-09-24

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA,as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： OLDFIELD, Edward, H. ,  LONSER, Russell, R. ,  GARMESTANI, Kayhan ,  BRECHBIEL, Martin, W.

IPC分类号： A61B5/055

CPC分类号： G01R33/5601 ,  A61B6/508 ,  A61K9/0085 ,  A61K49/0438 ,  A61K49/085 ,  A61K49/124 ,  A61K49/14 ,  G01R33/56308 ,  Y02A90/26

摘要： A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.

公开(公告)号：EP1545498A2

公开(公告)日：2005-06-29

申请号：EP03752034.3

申请日：2003-09-05

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： BRECHBIEL, Martin, W. ,  CHONG, Hyun-Soon

IPC分类号： A61K31/33 ,  A61K31/44 ,  A61P35/00 ,  C07D225/00 ,  C07D245/00 ,  C07D257/02

CPC分类号： A61K51/1051 ,  C07D257/02 ,  C07D257/10

摘要： Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N',N'',N''' -tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.

公开(公告)号：EP1420688A2

公开(公告)日：2004-05-26

申请号：EP02752092.3

申请日：2002-06-24

申请人： The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： BRECHBIEL, Martin, W. ,  KOBAYASHI, Hisataka

IPC分类号： A61B5/055 ,  A61K51/00

CPC分类号： A61K49/124

摘要： Macromolecular imaging agents comprising a polyalkylenimine dendrimer conjugated to a metal chelate are disclosed. In particular embodiment, the imaging agent is a diaminobutane-core polypropylenimine dendrimer having surface amino groups conjugated to gadolinium metal chelates. Administration of this gadolinium conjugate to a subject permits visualization of liver micrometastases as small as about 0.3mm in a magnetic resonance image of the subject's liver.