专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"KEW, Olen, M." 第 1 页

1.

发明公开
MODULATION OF REPLICATIVE FITNESS BY USING LESS FREQUENTLY USED SYNONYMOUS CODONS 有权
标题翻译：复制速度通过使用稀有金属二手同义密码子的调控

公开(公告)号：EP1797173A2

公开(公告)日：2007-06-20

申请号：EP05802766.5

申请日：2005-10-07

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KEW, Olen, M. , BURNS, Cara, C. , SHAW, Jing , CAMPAGNOLI, Raymond , QUAY, Jacqueline

IPC分类号： C12N5/10

CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476

摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

2.

发明授权
MODULATION OF REPLICATIVE FITNESS BY USING LESS FREQUENTLY USED SYNONYMOUS CODONS 有权
标题翻译：复制速度通过使用稀有金属二手同义密码子的调控

公开(公告)号：EP1797173B1

公开(公告)日：2014-05-14

申请号：EP05802766.5

申请日：2005-10-07

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KEW, Olen, M. , BURNS, Cara, C. , SHAW, Jing , CAMPAGNOLI, Raymond , QUAY, Jacqueline

IPC分类号： A61K39/00 , C07K14/245

CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476

摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.