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公开(公告)号：EP1331950A1
公开(公告)日：2003-08-06
申请号：EP01983146.0
申请日：2001-10-15
申请人： The Johns Hopkins University , Donahue, Kevin J. , Marban, Eduardo , Nagata, Koichi , Lawrence, John H., III
CPC分类号： A61K48/0016
摘要： The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
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公开(公告)号：EP1331950B1
公开(公告)日：2009-10-14
申请号：EP01983146.0
申请日：2001-10-15
申请人： THE JOHNS HOPKINS UNIVERSITY , Donahue, Kevin J. , Marban, Eduardo , Nagata, Koichi , Lawrence, John H., III
CPC分类号： A61K48/0016
摘要： The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
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