公开(公告)号：EP0771362A1

公开(公告)日：1997-05-07

申请号：EP95927253.0

申请日：1995-07-18

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NELSON, William, G. ,  ISAACS, William, B. ,  LEE, Wen-Hsiang

IPC分类号： C12N9 ,  C12N15 ,  C12Q1 ,  G01N33 ,  A61K48

CPC分类号： C12N9/1088 ,  A61K48/00 ,  C12N2799/027 ,  C12Q1/6886 ,  C12Q2600/154 ,  G01N33/573

摘要： A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.

公开(公告)号：EP0891550A1

公开(公告)日：1999-01-20

申请号：EP97920110.0

申请日：1997-04-02

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： TS'O, Paul, O., P. ,  WANG, Zheng-Pin ,  LESKO, Stephen, A. ,  NELSON, William, G. ,  PARTIN, Alan, W.

IPC分类号： C12N15 ,  C12N5 ,  C12Q1 ,  G01N33

CPC分类号： G01N33/57407 ,  G01N33/56966 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57488

摘要： The present invention provides for enriching rare cells in a fluid comprising the rare cells and non-rare cells. Examples of rare cells enriched include prostate cancer cells.

公开(公告)号：EP0771362B1

公开(公告)日：2002-10-23

申请号：EP95927253.5

申请日：1995-07-18

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NELSON, William, G. ,  ISAACS, William, B. ,  LEE, Wen-Hsiang

IPC分类号： C12Q1/68 ,  C12N9/10 ,  A61K48/00 ,  G01N33/577

CPC分类号： C12N9/1088 ,  A61K48/00 ,  C12N2799/027 ,  C12Q1/6886 ,  C12Q2600/154 ,  G01N33/573

摘要： A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.