专利检索 ap:("THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE" OR "THE GENERAL HOSPITAL CORPORATION") AND inv:"LEE, Tae-Ho" 第 1 页

1.

发明公开
CELL DEATH PROTEIN 失效
标题翻译：细胞死亡蛋白

公开(公告)号：EP0852627A1

公开(公告)日：1998-07-15

申请号：EP96911803.0

申请日：1996-04-18

申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION

发明人： LEDER, Philip , SEED, Brian , STRANGER, Ben, Z. , LEE, Tae-Ho , KIM, Emily

IPC分类号： G01N33 , A61K48 , C07K14 , C07K16 , C12N5 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K38 , C12R1

CPC分类号： C12N9/12 , A61K38/00 , C07K14/715 , C07K16/24

摘要： Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.