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1.发明公开TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR 失效炎症由特定硫酸酯酶的恩赐，和/或抑制剂治疗硫酸
公开(公告)号：EP0750511A1
公开(公告)日：1997-01-02
申请号：EP95914060.0
申请日：1995-03-15
CPC分类号： C07K14/70596 , A61K33/04 , A61K33/20 , A61K38/465 , C12Y301/06004 , C12Y301/06014 , A61K2300/00
摘要： Compositions are administered to a patient (preferably by injection and locally) to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroiditis, hemorrhagic shock, reperfusion injury during transplantation and multiple sclerosis. The compositions are pharmaceutically acceptable injectable formulations which include an active component in a pharmaceutically acceptable carrier. The active component is a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin. Removal of the sulfate from the ligand hinders the ability of the ligand to bind to its natural receptor (i.e. L-selectin) and thereby hinders a biochemical chain of events which results in inflammation.
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2.发明授权TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR 失效炎症由特定硫酸酯酶的恩赐，和/或抑制剂治疗硫酸
公开(公告)号：EP0750511B1
公开(公告)日：2003-06-11
申请号：EP95914060.9
申请日：1995-03-15
CPC分类号： C07K14/70596 , A61K33/04 , A61K33/20 , A61K38/465 , C12Y301/06004 , C12Y301/06014 , A61K2300/00
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