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1.发明授权ADENO-ASSOCIATED VIRUS SEROTYPE 1 NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME 有权核酸序列的腺相关病毒血清型我，和载体和宿主细胞含
公开(公告)号：EP1127150B1
公开(公告)日：2007-05-16
申请号：EP99961559.4
申请日：1999-11-02
发明人： WILSON, James, M. , XIAO, Weidong
CPC分类号： C12N15/86 , C07K14/005 , C12N2750/14122 , C12N2750/14143
摘要： The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
摘要翻译： 提供腺相关病毒（AAV）血清型1的核酸序列，因为是载体和含合成序列和其功能片段的宿主细胞。 所以提供的是通过衍生AAV-1载体递送基因的方法。
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2.发明公开COMPOSITIONS AND METHODS USEFUL FOR PRODUCTION OF RECOMBINANT VIRUSES WHICH REQUIRE HELPER VIRUSES 审中-公开组合物和方法重组病毒的生产，辅助病毒的必要性
公开(公告)号：EP1183380A1
公开(公告)日：2002-03-06
申请号：EP00902362.3
申请日：2000-01-07
发明人： XIAO, Weidong , WILSON, James, M.
CPC分类号： C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10351 , C12N2710/10352 , C12N2800/80
摘要： A method of producing recombinant viruses which require helper viruses for packaging is provided. The method uses a recombinant helper virus which has been designed to contain at least one rare-cutting restriction site (e.g., for I-SceI), a viral vector which is helper-dependent for packaging, and a recombinant host cell which is capable of expressing a rare-cutting restriction enzyme (e.g., I-SceI). The method involves transfecting or infecting the host cell with the helper virus and viral vector and incubating the cell under conditions which permit encapsidation of the viral vector in an adenovirus capside. Thereafter, the I-SceI expressed by the host cell digests the helper virus, permitting ready separation of the digested fragments of the helper virus from the packaged recombinant virus.
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3.发明公开ADENO-ASSOCIATED VIRUS SEROTYPE 1 NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME 有权核酸序列的腺相关病毒血清型我，和载体和宿主细胞含
公开(公告)号：EP1127150A2
公开(公告)日：2001-08-29
申请号：EP99961559.4
申请日：1999-11-02
发明人： WILSON, James, M. , XIAO, Weidong
CPC分类号： C12N15/86 , C07K14/005 , C12N2750/14122 , C12N2750/14143
摘要： The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
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