专利检索 ap:("THE UNITED STATES OF AMERICA, represented by the S") AND inv:"KWONG, Peter, D." 第 1 页

1.

发明公开
NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：中和抗体对HIV-1及其用途

公开(公告)号：EP2788376A1

公开(公告)日：2014-10-15

申请号：EP12855597.6

申请日：2012-12-10

申请人： THE UNITED STATES OF AMERICA, represented by the S

发明人： KWONG, Peter, D. , NABEL, Gary, J. , RUDICELL, Rebecca, S. , MASCOLA, John , CONNORS, Mark , GEORGIEV, Ivelin , ZHU, Jiang , KWON, Young, Do , ZHOU, Tongqing , YANG, Yongping , ZHANG, Baoshan , CHUANG, Gwo-yu , WU, Xueling , YANG, Zhi-yong , SHI, Wei

IPC分类号： C07K16/10 , A61K39/42 , A61P31/18 , C12N15/13 , G01N33/569

CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/56988

摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.