-
公开(公告)号：EP1123316A1
公开(公告)日：2001-08-16
申请号：EP99970666.6
申请日：1999-10-21
IPC分类号： C07K14/61 , C07K14/54 , C07K14/535 , G06F17/30
摘要： A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a Cα-Cβ vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein 'hits' so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.
-
公开(公告)号：EP1123316B1
公开(公告)日：2011-03-02
申请号：EP99970666.6
申请日：1999-10-21
IPC分类号： G06F19/00
摘要： A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a Cα-Cβ vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein 'hits' so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.
-
搜索结果
2 条记录 (耗时 0.01 秒)
