公开(公告)号：EP0380588A4

公开(公告)日：1991-04-03

申请号：EP88910246

申请日：1988-09-28

申请人： THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION

发明人： KENNEDY, THOMAS, P. ,  KABALKA, GEORGE, W.

IPC分类号： C07D307/81 ,  A61K31/34 ,  A61K31/343 ,  A61P9/00 ,  A61P9/08 ,  C07D307/80 ,  C07D307/18 ,  C07D405/10 ,  C07D407/10

CPC分类号： C07D307/80

摘要： The disclosure relates to compounds of formula (I) and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R5 is a lower alkyl group, wherein R6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrrolidino, and morpholino groups wherein Y1 and Y2 are identical and are hydrogen, a halogen, methyl or ethyl and n is an integer in the range of 1-5. They are useful in treating arrhythmic conditions and conditions for which treatment with a vasodilator is indicated.