公开(公告)号：EP3200815A4

公开(公告)日：2018-04-25

申请号：EP15847792

申请日：2015-09-30

申请人： THE WISTAR INST OF ANATOMY AND BIOLOGY

发明人： PERALES-PUCHALT ALFREDO ,  CONEJO-GARCIA JOSE R

IPC分类号： A61K38/24

CPC分类号： C07K14/59 ,  A61K38/00 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70564 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03

摘要： A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating hormone sequence, e.g., an FSHp sequence, or fragment thereof, which ligand binds to human follicle stimulating hormone (FSH) receptor, linked to either (a) a nucleic acid sequence that encodes an extracellular hinge domain, a transmembrane domain, a co-stimulatory signaling region, and a signaling endodomain; or (b) a nucleic acid sequence that encodes a ligand that binds to NKG2D. The vector containing the nucleic acid sequence, the chimeric proteins so encoded, and modified T cells expressing the chimeric protein, as well as method of using these compositions for the treatment of FSHR-expressing cancers or tumor cells are also provided.