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1.发明授权
公开(公告)号：EP1511764B1
公开(公告)日：2012-08-22
申请号：EP03735223.4
申请日：2003-06-11
摘要： The invention relates to compositions which are useful for inhibiting prostaglandin F2alpha receptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat preterm labor and dysmenorrhea are disclosed.
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2.发明公开
公开(公告)号：EP1511764A2
公开(公告)日：2005-03-09
申请号：EP03735223.4
申请日：2003-06-11
摘要： The invention relates to compositions which are useful for inhibiting prostaglandin F2alpha receptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat preterm labor and dysmenorrhea are disclosed.
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公开(公告)号：EP1546108A1
公开(公告)日：2005-06-29
申请号：EP03793533.5
申请日：2003-08-29
IPC分类号： C07D213/74 , C07D209/14 , C07D213/40 , C07D211/58 , C07D215/38 , C07D217/02 , C07D209/08 , C07D487/04 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4045 , C07C237/24
CPC分类号： C07C237/24 , C07C2601/14 , C07D209/08 , C07D209/16 , C07D213/40 , C07D213/75 , C07D215/42 , C07D473/34
摘要： Allylic compounds represented by the formula (I) are provided, wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.
摘要翻译： 提供由式（I）表示的烯丙基化合物，其中R 1至R 8，m，n，A和X各自如本说明书中所定义。 这些化合物可以抑制Rho激酶，并且通过诱导轴突生长和再生以及通过抑制Rho激酶在其中涉及Rho激酶的疾病状态来治疗中枢和周围神经系统中受损神经的修复可以发挥效用。 所述化合物是相对细胞可渗透的，并且其药物组合物可以促进神经突生长，并且也可用于预防恶性疾病中的细胞增殖。
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