公开(公告)号：EP1185492A1

公开(公告)日：2002-03-13

申请号：EP00906477.5

申请日：2000-02-24

申请人： THOMAS SWAN AND CO., LTD.

发明人： POLIAKOFF, Martyn ,  GRAY, William Keith ,  SWAN, Thomas Macklyn,Thomas Swan & Co. Ltd. ,  ROSS, Stephen Keith,Thomas Swan & Co. Ltd. ,  WIELAND, Stefan ,  ROEDER, Stefan

IPC分类号： C07C41/09 ,  C07C41/50 ,  C07C1/20

CPC分类号： C07D317/12 ,  C07C1/24 ,  C07C41/09 ,  C07D307/08 ,  Y02P20/544 ,  C07C11/10 ,  C07C43/04 ,  C07C43/13 ,  C07C43/10

摘要： The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.