专利检索 ap:("TOKYO UNIVERSITY OF SCIENCE FOUNDATION") AND inv:"NARITA, Takumi" 第 1 页

1.

发明公开
MESENCHYMAL STEM CELLS AND ADIPOCYTES FOR PREPARING MITOKINE MIXTURE, AND THERAPEUTIC OR PROPHYLACTIC DRUG 审中-公开

公开(公告)号：EP4296355A1

公开(公告)日：2023-12-27

申请号：EP22756235.2

申请日：2022-02-16

申请人： TOKYO UNIVERSITY OF SCIENCE FOUNDATION

发明人： HIGAMI, Yoshikazu , KOBAYASHI, Masaki , NARITA, Takumi , TAKI, Kanari , HIRAO, Yuto

IPC分类号： C12N5/10 , A61K35/28 , A61K35/35 , A61P3/04 , A61P9/10 , A61P13/12 , A61P29/00 , A61P31/04 , C07K14/475 , C07K14/50 , C12N5/077 , C12N5/0775 , C12N15/90 , C12P21/02 , A01K67/027

摘要： Provided are: a non-human animal or a part of the same in which the function of Mipep gene is totally or partially lost in adipose tissues or the expression level of Mipep gene in adipose tissues is lowered compared to a wild type; and mesenchymal stem cells or adipocytes in which the function of Mipep gene is totally or partially lost or the expression level of Mipep gene is lowered compared to a wild type. Also provided are: a therapeutic or prophylactic drug that comprises the aforesaid mesenchymal stem cells or adipocytes or a culture supernatant thereof; and a method for preparing a mitokine mixture using the aforesaid non-human cells, mesenchymal stem cells or adipocytes.