公开(公告)号：EP2682121A4

公开(公告)日：2014-07-30

申请号：EP12751830

申请日：2012-01-31

申请人： TONGJI HOSPITAL TONGJI MEDICAL COLLEGE HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTD

发明人： ZHOU PING ,  JIANG FENGCHAO

IPC分类号： A61K31/496 ,  A61P7/00 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06

CPC分类号： C07D417/12 ,  A61K31/496

摘要： Provided in the present invention is a pharmaceutical use of aminothiazole MyD88 specificity inhibitor, for use in preparing an immunosuppressant medicament, an anti-inflammatory medicament, a protection agent for post-ischemia reperfusion injury, and a preventative medicament for endotoxemia and sepsis.

摘要翻译： 在本发明中提供了用于制备免疫抑制剂药物，抗炎药物，缺血后再灌注损伤保护剂和用于内毒素血症和败血症的预防药物的氨基噻唑MyD88特异性抑制剂的药物用途。

公开(公告)号：EP2682390A4

公开(公告)日：2014-07-23

申请号：EP12752555

申请日：2012-02-01

申请人： UNIV HUAZHONG SCIENCE TECH ,  HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTD

发明人： JIANG FENGCHAO ,  ZHOU PING ,  CHEN JIANGUO ,  WANG YUE ,  CAO BAOSHUAI ,  YAN JIA

IPC分类号： C07D277/46 ,  A61K31/425 ,  A61P3/10 ,  A61P25/00 ,  A61P37/00 ,  C07D277/42 ,  C07D417/12

CPC分类号： C07D277/42 ,  C07D277/46 ,  C07D295/14 ,  C07D417/12

摘要： The present invention relates to the preparation of a 2-aminothiazole derivative having a structure as formula (I) and a therapeutic effect thereof for Alzheimer's disease (AD), and a therapeutic effect thereof against transplant rejection, autoimmune diseases, ischemia-reperfusion injury, chronic inflammation response, endotoxemia, and other diseases.