公开(公告)号：EP1913946B1

公开(公告)日：2014-03-05

申请号：EP06767982.9

申请日：2006-07-07

申请人： TORAY INDUSTRIES, INC.

发明人： TAKENAKA, Masahiko ,  YAMANE, Yoshihisa ,  IDA, Nobutaka ,  KURUMATANI, Hajimu

IPC分类号： A61K31/5578 ,  A61K31/5585 ,  A61P13/12 ,  C07D307/93

CPC分类号： A61K31/343 ,  A61K31/5578 ,  A61K31/5585 ,  C07D307/93

摘要： A therapeutic agent and a treatment method for uremia of human and animals, which therapeutic agent can be easily taken, has lower side effects, and which is not expensive in view of medical economics, are disclosed. The therapeutic agent for uremia in patients suffering from chronic renal failure comprises as an effective ingredient a prostaglandin I 2 derivative having a specific structure, such as beraprost sodium. The therapeutic agent for uremia ameliorates the uremia concurred in patients with chronic renal failure without accompanying side effects, and restoration of decreased appetite, improvements in activities, increase in body weight and the like are achieved. The therapeutic effect of uremia is clear alleviation or disappearance of symptoms of uremia grasped as clinical symptoms, observed in the state of renal failure, especially even in spite of the state wherein the decrease in renal function is progressed.

公开(公告)号：EP1913946A1

公开(公告)日：2008-04-23

申请号：EP06767982.9

申请日：2006-07-07

申请人： TORAY INDUSTRIES, INC.

发明人： TAKENAKA, Masahiko ,  YAMANE, Yoshihisa ,  IDA, Nobutaka ,  KURUMATANI, Hajimu

IPC分类号： A61K31/5578 ,  A61K31/5585 ,  A61P13/12 ,  C07D307/93

CPC分类号： A61K31/343 ,  A61K31/5578 ,  A61K31/5585 ,  C07D307/93

摘要： A therapeutic agent and a treatment method for uremia of human and animals, which therapeutic agent can be easily taken, has lower side effects, and which is not expensive in view of medical economics, are disclosed. The therapeutic agent for uremia in patients suffering from chronic renal failure comprises as an effective ingredient a prostaglandin I 2 derivative having a specific structure, such as beraprost sodium. The therapeutic agent for uremia ameliorates the uremia concurred in patients with chronic renal failure without accompanying side effects, and restoration of decreased appetite, improvements in activities, increase in body weight and the like are achieved. The therapeutic effect of uremia is clear alleviation or disappearance of symptoms of uremia grasped as clinical symptoms, observed in the state of renal failure, especially even in spite of the state wherein the decrease in renal function is progressed.

摘要翻译： 公开了治疗剂和治疗剂可以容易地服用的治疗剂和治疗方法，其副作用较小，并且在医学经济学方面不贵。 用于患有慢性肾功能衰竭的患者的尿毒症治疗剂包括作为有效成分的具有特定结构的前列腺素I 2衍生物，例如贝前列素钠。 用于尿毒症的治疗剂可以改善慢性肾功能衰竭患者的尿毒症，而不伴随副作用，恢复食欲降低，活动改善，体重增加等。 尿毒症的治疗效果是在肾功能衰竭状态下观察到的作为临床症状的尿毒症症状明显缓解或消失，特别是即使肾功能下降进行的状态也是如此。