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公开(公告)号：EP1221937A2
公开(公告)日：2002-07-17
申请号：EP00968669.2
申请日：2000-10-04
CPC分类号： A61K9/0024 , A61L27/24 , A61L27/3804 , A61L27/44 , A61L27/54 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/414 , A61L2300/438
摘要： A composition having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin: a) a plurality of vertebrate cells; b) a plurality of microcarriers; and c) an agent such as a factor that promotes vascularization, a cytokine, a growth factor, or ascorbic acid. The invention also features a method of delivering a polypeptide to an animal. The method involves introducing into the animal a fluid mixture containing: a) a population of cultured vertebrate cells genetically engineered to express the polypeptide; and b) a plurality of microcarriers.
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公开(公告)号：EP1221937B1
公开(公告)日：2004-12-15
申请号：EP00968669.2
申请日：2000-10-04
CPC分类号： A61K9/0024 , A61L27/24 , A61L27/3804 , A61L27/44 , A61L27/54 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/414 , A61L2300/438
摘要： A composition having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin: a) a plurality of vertebrate cells; b) a plurality of microcarriers; and c) an agent such as a factor that promotes vascularization, a cytokine, a growth factor, or ascorbic acid. The invention also features a method of delivering a polypeptide to an animal. The method involves introducing into the animal a fluid mixture containing: a) a population of cultured vertebrate cells genetically engineered to express the polypeptide; and b) a plurality of microcarriers.
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