公开(公告)号：EP0744894A1

公开(公告)日：1996-12-04

申请号：EP95909296.0

申请日：1995-01-27

申请人： TRUSTEES OF BOSTON UNIVERSITY ,  UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

发明人： CANTOR, Charles, R. ,  NIEMEYER, Christof, M. ,  SMITH, Cassandra, L. ,  SANO, Takeshi ,  HNATOWICH, Donald, J. ,  RUSCKOWSKI, Mary

IPC分类号： G01N33 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K47 ,  A61K49 ,  A61K51 ,  A61P31 ,  A61P35 ,  C03C17 ,  C07H21 ,  C12N15 ,  C12Q1

CPC分类号： B82Y5/00 ,  A61K47/55 ,  A61K47/557 ,  A61K47/6949 ,  A61K51/1268 ,  C03C17/30 ,  C03C17/3405 ,  C12Q1/6804 ,  C12Q1/682 ,  Y10S977/80 ,  Y10S977/808 ,  Y10S977/898 ,  Y10S977/906 ,  Y10S977/92

摘要： The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.