公开(公告)号：EP0806416A4

公开(公告)日：1998-04-15

申请号：EP95941572

申请日：1995-12-26

申请人： TSUMURA & CO ,  ZHU DAYUAN ,  TANG XICAN ,  LIN JINLAI ,  ZHU CHENG ,  SHEN JINGKANG ,  WU GUANSONG ,  JIANG SHANHAO ,  YAMAGUCHI TAKUJI ,  TANAKA KAZUHIRO ,  WAKANATSU TAKESHI ,  NISHIMURA HIROAKI

发明人： ZHU DAYUAN ,  TANG XICAN ,  LIN JINLAI ,  ZHU CHENG ,  SHEN JINGKANG ,  WU GUANSONG ,  JIANG SHANHAO ,  YAMAGUCHI TAKUJI ,  TANAKA KAZUHIRO ,  WAKANATSU TAKESHI ,  NISHIMURA HIROAKI

IPC分类号： A61K31/435 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4748 ,  A61K36/18 ,  A61P21/00 ,  A61P25/28 ,  C07D221/22 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

CPC分类号： C07D401/06 ,  C07D221/22 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

摘要： The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is (a), or R' and Y together form =CH; R is (C1-C5)alkyl, (b), (c), (d), wherein n is 0 or 1, X is H, (C1-C5)alkyl; (C1-C5)alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis -(C1-C5)alkyl; -(CH2mCOOZ, wherein m=0∩5, Z is H or (C1-C5)alkyl; -CH=CH-G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl1 substituted by (C1-C5)alkyl at the nitrogen atom; R' is H, (C1-C5)alkyl, pyridoyl, benzoyl substituted by (C1-C5)alkyloxy; R' is H or (C1-C5)alkyl; processes for their manufacture and their use as acetyl cholinesterase inhibitor.