公开(公告)号：EP1142875A1

公开(公告)日：2001-10-10

申请号：EP00900175.1

申请日：2000-01-11

申请人： TSUMURA & CO.

发明人： HASEGAWA, Yoshihiro, Tsumura & Co. ,  SHINDOU, Shouichirou, Tsumura & Co. ,  HATTORI, Tomohisa, Tsumura & Co. ,  OBATA, Tatsuhiro, Tsumura & Co. ,  HORIUCHI, Fumiko, Tsumura & Co. ,  HAYAKAWA, Hiroyuki, Tsumura & Co. ,  KUMAZAWA, Hiroaki, Tsumura & Co.

IPC分类号： C07D213/40 ,  A61K31/4406 ,  A61P37/02 ,  A61P13/12 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D213/40

摘要： The invention relates to cinnamamide derivatives having the following formula (I):
wherein

R 1 represents a hydroxyl group, a C 1-6 -alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group;
R 2 and R 3 are same or different, each of which represents a hydrogen atom, a halogen atom or a C 1-4 -alkyl group;
R 4 represents a hydrogen atom or a C 1-6 -alkyl group;
R 5 represents a hydrogen atom, a C 1-6 -alkyl group or an aryl group;
R 6 represents a hydrogen atom, a C 1-6 -alkyl group, a cyano group or a C 1-6 -alkoxy-carbonyl group;
W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group;
X and Y are same or different, each of which represents an oxygen atom or a sulfur atom;
m represents an integer of 0 to 2;
n represents an integer of 1 to 3; and
   when m is 0, a group: -C(R 2 )(R 3 )-W- may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.