公开(公告)号：EP2947086B1

公开(公告)日：2018-01-03

申请号：EP14836782.4

申请日：2014-08-11

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： IGUCHI, Satoru ,  HOSOI, Fumihito ,  SAGARA, Takeshi

IPC分类号： C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07F5/02

摘要： Provided is a novel compound having BTK inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention and/or treatment of a disease associated with BTK, particularly cancer, based on BTK inhibitory action. A compound represented by formula (I) [wherein R 1 to R 3 , W, A, Y and Z respectively have the meanings as defined in the specification], or a salt thereof is disclosed.

公开(公告)号：EP3120852B1

公开(公告)日：2019-05-01

申请号：EP16743556.9

申请日：2016-01-29

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： HOSOI, Fumihito ,  NAKACHI, Yoshinori ,  KAJIWARA, Daisuke

IPC分类号： A61K31/519 ,  A61P11/02 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  C07D487/04 ,  C07D519/00

公开(公告)号：EP3120852A1

公开(公告)日：2017-01-25

申请号：EP16743556.9

申请日：2016-01-29

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： HOSOI, Fumihito ,  NAKACHI, Yoshinori ,  KAJIWARA, Daisuke

IPC分类号： A61K31/519 ,  A61P11/02 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  C07D487/04 ,  C07D519/00

CPC分类号： A61K31/519 ,  C07D487/04 ,  C07D519/00

摘要： Provided is a preventive and/or therapeutic agent for immune diseases containing a compound having a BTK inhibitory activity or a salt thereof, as an active ingredient.
A preventive and/or therapeutic agent of immune diseases, comprising a compound represented by Formula (I), where R 1 to R 3 , W, X, Y, Z, and n represent those as defined in the specification, or a salt thereof, as an active ingredient.

公开(公告)号：EP2947086A1

公开(公告)日：2015-11-25

申请号：EP14836782.4

申请日：2014-08-11

申请人： Taiho Pharmaceutical Co., Ltd.

发明人： IGUCHI, Satoru ,  HOSOI, Fumihito ,  SAGARA, Takeshi

IPC分类号： C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  C07F5/02

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07F5/02

摘要： Provided is a novel compound having BTK inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention and/or treatment of a disease associated with BTK, particularly cancer, based on BTK inhibitory action. A compound represented by formula (I) [wherein R 1 to R 3 , W, A, Y and Z respectively have the meanings as defined in the specification], or a salt thereof is disclosed.

摘要翻译： 提供具有BTK抑制作用和细胞增殖抑制作用的新化合物。 还提供了一种基于BTK抑制作用的用于预防和/或治疗与BTK，特别是癌症相关的疾病的药物。 式（I）表示的化合物或其盐，其中R 1〜R 3，W，A，Y和Z分别具有如说明书中所定义的含义。